In a skillet over medium-high heat, add the ground beef and all the seasonings: onion powder, oregano, garlic powder, paprika, salt, and black pepper. Cook, breaking it up with a spatula (or my favorite kitchen tool), until browned and fully cooked through (about 7–10 minutes). Set aside.
In a small bowl, whisk together the mayo, ketchup, mustard, pickle juice, dill relish, garlic powder, onion powder, paprika, and vinegar. Start with ½ teaspoon of vinegar, taste, and adjust if you want a little more tang.
In individual bowls, layer a generous base of lettuce, then top with tomatoes, pickles, red onion, and cheese if using. Add a scoop of the cooked ground beef.
Spoon the special burger sauce generously over the top.
Notes
Customize the toppings to your liking. Try adding different cheeses, bacon, chives, etc.